Selected Publications

NEURAL CIRCUITS AND BEHAVIORS

  • T. Fore and B. Zhang (2014). Intersectional Strategies for Cell Type Specific Expression and Transsynaptic Labeling. In: Behavioral Genetics of the Fly (Drosophila melanogaster), Ed. Josh Dubnau. Cambridge University Press (in press).
  • B. Kottler, H. Bao, O. Zalucki, W. Imlach, M. Troup, B. van Alphen, A. Paulk, B. Zhang and B. van Swinderen (2013). A sleep/wake circuit controls isoflurane sensitivity in Drosophila. Current Biology 23: 594-598.
  • T. R. Fore, A. A. Ojwang, M. L. Warner, X.Y. Peng, C. A. Springer, R. A. Bohm, W. P. Welch, L. K. Goodnight, H. Bao, and B. Zhang (2011). Mapping and application of enhancer-trap flippase expression in larval and adult Drosophila CNS. J Vis Exp. 52
  • R.A. Bohm, W.P. Welch, L.K. Goodnight, L.W. Cox, L.G. Henry, T.C. Gunter, H. Bao, and B. Zhang (2010). A genetic mosaic approach for neural circuit mapping in Drosophila. Proc Natl Acad Sci U S A. 107: 16378-16383. [Featured on the cover]
  • V. G. Martinez, C. S. Javadi, E. Ngo, L. Ngo, R.D. Lagow, and B. Zhang (2007). Age-related changes in climbing behavior and neural circuit physiology in Drosophila. Dev. Neurobiol. 67: 778-791.

SYNAPSE DEVELOPMENT, FUNCTION, AND PLASTICITY

  • P.A. Vanlandingham, T.R. Fore, L.R. Chastain, S.M. Royer, H. Bao, N.E. Reist, and B. Zhang (2013). Epsin 1 promotes synaptic growth by enhancing BMP signal levels in motoneuron nuclei. PLoS One 8(6): e65997.
  • Y-J Kim, H. Bao, L. Bonanno, B. Zhang and M. Serpe (2012). Drosophila Neto is essential for clustering glutamate receptors at the neuromuscular junction. Genes and Development, 26: 974-987. [Featured on the cover]
  • H. Bao, N. Reist, and B. Zhang (2008). The Drosophila Epsin 1 Is required for ubiquitin-dependent synaptic growth and function, but not for synaptic vesicle recycling. Traffic 9: 2190-2205.
  • H. Bao, M. Berlanga, M. S. Xue, S. Hapip, R. W. Daniels, J. M. Mendenhall, A. Alcantara, and B. Zhang (2007). The atypical cadherin receptor Flamingo regulates synaptogenesis and helps prevent axonal and synaptic degeneration in Drosophila. Molecular and Cellular Neuroscience, 34: 662-678. [Featured on the cover].
  • R. D. Lagow, H. Bao, E. N. Cohen, R. W. Daniels, W. H. Williams, G. T. Macleod, R. B. Sutton, and B. Zhang (2007). Modification of a hydrophobic layer by a point mutation in syntaxin 1A regulates the rate of synaptic vesicle fusion. PLoS Biol, 5(4): e72. DOI:10.1371. page 0800-0817.
  • G. Marques, H. Bao, T. Haerry, P. Duchek, M. J. Shimell, B. Zhang, and M. B. O’Connor (2002). The Drosophila BMP type II receptor wishful thinking regulates neuromuscular synapse morphology and function. Neuron 33: 529-543.

MODELING HUMAN NEUROLOGICAL DISORDERS

  • P. A. Vanlandingham, M. Padash-Barmchi, S. Royer, R. Green, H. Bao, N. Reist and B. Zhang (2014). AP180 couples protein retrieval to clathrin-mediated endocytosis of  synaptic vesicles. Traffic (in press).
  • E. L. Kumimoto, T. R. Fore, and B. Zhang (2013). Transcriptome profiling following neuronal and glial expression of ALS-linked SOD1 in Drosophila. G3: Genes Genomes and Genetics. 3: 695-708.
  • R. Islam, E.L. Kumimoto, H. Bao and B. Zhang (2012). ALS-linked SOD1 in glial cells enhances ß-N-Methylamino L-Alanine (BMAA)-induced toxicity in Drosophila [v1; ref status: indexed, http://f1000r.es/S4BZRP] F1000 Research 1:47 (doi: 10.3410/f1000research.1-47.v1)
  • J. M. Tauber, P. A. Vanlandingham, and B. Zhang (2011). Elevated levels of the vesicular monoamine transporter and a novel repetitive behavior in the Drosophila model of fragile X syndrome. PLoS One, 6(11): e27100. doi:10.1371/journal.pone.0027100.
  • A. Chai, J. Withers, Y. H. Koh, K. Parry, H. Bao, B. Zhang, V. Budnik, G. Pennetta (2008). hVAPB, the causative gene of a heterogeneous group of motor neuron diseases in humans, is functionally interchangeable with its Drosophila homologue DVAP-33A at the Neuromuscular Junction. Human Molecular Genetics 17: 266-80.
  • M. R. Watson, R. D. Lagow, K. Xu, B. Zhang, and N. M. Bonini (2008). A Drosophila model for SOD-linked amyotrophic lateral sclerosis reveals motor neuron damage by SOD1. JBC 283: 24972-81. [Selected as a Paper of the Week and featured on the cover]
  • H. Bao, R. W. Daniels, G. T. Macleod, M. P. Charlton, H. L. Atwood, and B. Zhang (2005). AP180 maintains the distribution of synaptic and vesicle proteins in the nerve terminal and indirectly regulates the efficacy of Ca2+-triggered exocytosis. Journal of Neurophysiology, 94: 1888-1903. (Note: AP180 homolog PiCALM is a risk factor for Alzheimer’s disease)
  • Y. Mao, J. Chen, J. A. Maynard, B. Zhang, and F. A. Quiocho (2001). A novel all helix fold of the AP180 amino-terminal domain for phosphoinositide binding and clathrin assembly in synaptic vesicle endocytosis. Cell 104: 433-440.
  • B. Zhang, Y. H. Koh, R. B. Beckstead, V. Budnik, B. Ganetzky, and H. J. Bellen (1998). Synaptic vesicle size and number are regulated by a clathrin adaptor protein required for endocytosis. Neuron  21: 1465-1475.